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Updates on CGD Patients (2013)
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Do I have CGD?
Warning Signs That You May Have CGD
Keep in mind that CGD is very rare—consult your doctor.
  • Infections that may require the use of IV antibiotics/antifungals to clear
  • Pneumonias that occur frequently and/or difficult to cure
  • Lymph nodes in the neck or groin that are swollen
  • Growth retardation or failure to gain weight
  • Abnormal wound healing due to granulation
  • Colitis or persistent diarrhea
  • Infecting organisms such as: Aspergillus, Nocardia, Burkholderia cepacia, Staphylococcus aureus, Serratia marcescens, Listeria, Salmonella, E. coli, Klebsiella, and Candida
  • Bone infections
  • Abscesses in organs such as the lung, liver, spleen or brain
  • Skin infections, such as abscesses or cellulitis
  • Granulomas of the stomach, urinary track, or esophagus
  • Perianal or perirectal abscesses
  • Septicemia
  • Unexplained fevers
How does CGD differ from other primary immune deficiencies (PIDs)?
CGD is one of the over 185 PIDs. Unlike many PIDs, CGD patients have the ability to fight viral, but not bacterial or fungal infections. The cell can engulf the germ but the cell lacks the oxygen burst to kill the germ.
Diagnostic Tests for CGD
Dihydrorhodamine test (DHR)
The DHR test has widely replaced the NBT test. It is more accurate. Whole blood is stained with DHR, incubated, and stimulated to produce superoxide radicals which oxidize DHR to rhodamin in cells with normal function. In CGD (X-linked) this does not happen. In the autosomal recessive type, there may be some activity.
Nitroblue tetrazolium dye reduction test (NBT)
The NBT test checks to see if cells can change a colorless chemical (NBT) into a deep blue color, formazan, which is visible on microscopic inspection. In CGD the color does not turn blue, meaning they are not producing reactive oxygen species which is needed to kill bacteria.
What is not CGD
If there are terms such as “granulomatous” “calcified granulomata” “old granulomata” “hilar calcification” “residuals of previous granulomatous disease” on an x-ray report, it suggests that there was an infection, probably many years before, by a bacteria or fungus that tends to form granulomas, which are a particular kind of inflammatory reaction. This could have been pneumonia, etc. This does not mean that there is currently an active infection. This is also not the disease CGD. Many people confuse the two terms.
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